Hsi Wei
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Understand what happens in the brains of individuals experiencing psychosis related language difficulties down to a millisecond precision.
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Hi, I am Hsi Tiana Wei, a postdoctoral researcher at McGill University and Douglas Mental Health Institute, and I'm excited to share with you what we found.
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Schizophrenic patients struggle with daily communication in the form of flattened affect.
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Reduced and disorganized speech. To study speech, which is such a dynamic behavioral symptom.
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MEG is an excellent neuroimaging tool that allows us to record high precision of spatial temporal, spectral.
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And network level connectivity information. And these are all neuronal aspects that have shown deviations in schizophrenic patients.
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And importantly, without understanding the associations between these deviated neural dynamics with communicative symptoms and clinical symptoms in schizophrenic patients.
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The development of treatments focusing on neurochemical alterations using drugs or neural oscillatory modulations using non-invasive brain stimulations would be considerably limited.
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So to improve the understanding of these associations, the current study that we ran, recruiting We are recruiting 25 schizophrenic patients and 25 healthy controls.
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For three main domains of data. Including one session of MEG recording during a sensorimotor task so that we can characterize their neural dynamic.
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And a natural speech task where we will extract the linguistic and acoustic features using large language models.
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And a battery of clinical assessments. This is a rich data set that allowed us to look into the associations and interactions between neural dynamics, speech, and clinical symptoms in our patients and control groups.
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So we're not only looking at factors and features that differentiate patients from control.
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We're also looking into individual differences within each population group. So come to my presentation on April 1st at 5 p.m. In Regency Ballroom C.
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To hear more about what we found and discuss how this study can inform the development of neuromodulatory treatments for psychosis. Looking forward to seeing you there.
